Lecozotan HCl (SRA-333) is a potent and selective 5-HT antagonist that significantly enhances KCl-stimulated glutamate and acetylcholine release from the hippocampal dentate gyrus and has cognitive enhancing properties. Chronic administration of Lecozotan HCl did not induce 5-HT(1A) receptor tolerance or desensitization in a behavioral model demonstrating 5-HT(1A) receptor function.

LP-533401 hydrochloride 是色氨酸羟化酶 1 (tryptophan hydroxylase 1) 抑制剂，可以调节肠道中血清素的产生。

一种非典型抗精神病药，对血清素 5HT2A (Ki = 5.6 nM)、多巴胺 D2 (Ki = 6.3 nM) 和 D3 (Ki = 7.1 nM) 以及去甲肾上腺素 α1 受体 (Ki = 0.36 nM) 具有高亲和力。